The overlap of the transcription factors was identified as the common putative transcription factors of 5 hub susceptibility genes in skeletal muscle of T2DM, including ER-alpha, YY1, GR-beta, GR-alpha, C/EBP beta, TFIID. The DNA-binding sequence logs of YY1 and C/EBP in the JASPAR database were shown in Fig. 6. The gene discussed is YY1; the disease is type 2 diabetes mellitus.