In association with these glial Cx changes, we also found (6) DO type demyelination with massive infiltration of CD68‐positive microglia/macrophages and a considerable number of T cells but not B cells in early‐stage MSA lesions, and (7) nodal proteins, such as claudin‐11/OSP, NFASC, and Caspr1, gradually decreased with advancing stage. Here, NFASC is linked to multiple system atrophy.