PGR and endometrial cancer: Metformin can promote progesterone receptor expression and has been used in combination with progestin for the conservative management of patients with endometrial cancer and atypical endometrial hyperplasia.17 The combination of hysteroscopic resection followed by progestin therapy has also been reported in fertility-sparing treatment, achieving a high response rate.18 GnRHa is an alternative to conservative treatment for endometrial diseases.