While downregulated in the ID subgroup, B, M, and lesser T cell subgroups showed upregulated signaling of several chemokines (CXCL9/10/11, CCL3/13/18) to their cognate receptors on T and myeloid cell subsets, suggesting that cancer-cell-secreted chemokine gradients contribute to immune infiltration.44 This evidence concerns the gene CCL3 and cancer.