CD4 and cancer: Unsupervised clustering on batch-corrected cell-type fractions revealed four distinct tumor immune phenotypes (Figure 2A): (1) immune-deserted (ID) tumors (i.e., no significant immune cell infiltration but a high cancer cell fraction); (2) the subtype of tumors with B cell dominance (B; B cell, plasma cell, mast cells); (3) the subtype of tumors with myeloid dominance (M; macrophage/monocyte); and (4) the subtype of tumors with T cell dominance (T; CD8+, CD4+, T regulatory cells).