SPP1 and lung carcinoma: Conversely, in LUSC cancer cells, there is upregulation of pro-migratory SPP1 signaling41 that has previously been reported as upregulated in lung cancer tissue particularly of squamous histology,42 as well as an upregulation of Jagged1 (JAG1), which induces NOTCH, thereby promoting tumor progression and regulating the tumor immune microenvironment via, e.g., neutrophil recruitment.43