Previous work has establishedseveral mRNAs of interest for PCa prognostics, including both androgenreceptor (AR) variant 7 (AR-V7) and Yes-associated protein 1 (YAP1)mRNA.12,13 AR-V7 is deficient of the ligand bindingdomain (LBD) which normally makes the AR a ligand-activated transcriptionfactor, as a result it is constitutively active. The gene discussed is YAP1; the disease is posterior cortical atrophy.