CXCR4 and age-related macular degeneration: The SDF-1/CXCR4 axis plays important roles in maintaining the HSC pool and in regulating HSC mobilization and homing.28-30 Single AMD treatment rapidly promotes HSPC mobilization into PB, but its long-term administration may induce hematopoietic damage via impaired retention of the SDF-1/CXCR4 axis.31-33 Here, we demonstrate that different from K14-Cre;c-Ang1 mice, Col2.3-Cre;c-Ang1 mice did not exhibit impaired BM retention and senescence of HSCs and anemic disorder, and these differences were correlated with the SDF-1/CXCR4 retention axis.