One report showed that megakaryopoiesis is more sensitively affected by dysregulated GATA-1 function than erythropoiesis.42 Based on the effects of Tie2 inhibitor on GATA-1 expression and production of platelets in transgenic mice, we postulated that activation of the Ang1/Tie2 signaling axis may directly cause thrombocytopenic damage rather than anemia via dysregulated GATA-1 expression in MP cells. The gene discussed is GATA1; the disease is anemia (phenotype).