DNM1 and cancer: In an effort to understand drivers of internalization, we blocked microtubule polymerization, clathrin-mediated endocytosis, caveolae-dependent endocytosis, and dynamin with nocodazole, chlorpromazine, nystatin, and dynasore, respectively, and observed that the increased uptake of KPC cells treated with P(Glu-co-Lys)1:5-GNR compared to PEGylated GNR (PEG-GNR) can be reversed by nocodazole, chlorpromazine, and nystatin but not dynasore, suggesting that active transport across the cell membrane also contributes to internalization by cancer cells in an acidotic environment (fig.