Consequently, both these anti-apoptotic proteins were down-regulated with increasing concentration of anti-PD-L1 mAb (Fig 8A and 8B), which was correlated with augmentation of apoptosis in anti-PD-L1-treated H460 cells, illustrating its potentiality to sensitize anoikis in highly metastatic lung cancer cells. Here, CD274 is linked to lung cancer.