It was worth noted that plant-produced anti-PD-L1 antibody at 0.5–1.0 μg/mL significantly diminished viable cells under detachment condition early at 3 h (Fig 7A) and induced apoptotic cell death after 24 h (Fig 7B–7E) in comparison with wild type plant extract (S1 Fig), signifying the capability of anoikis sensitization and preventing the formation of metastatic malignant tumors. This evidence concerns the gene CD274 and cancer.