Although the treatment with plant-produced anti-PD-L1 antibody (0.1–1.0 μg/mL) did not cause significant cytotoxicity in human non-small cell lung cancer cells cultured under attachment condition (Fig 6), the sensitizing effect on detachment-induced cells that is a crucial step in metastatic process was further evaluated in anti-PD-L1-treated H460 cells. Here, CD274 is linked to non-small cell lung carcinoma.