PD-1/PD-L1 checkpoint is associated with autoimmune response of T-cells and interestingly, PD-L1 ligands are up-regulated in many tumor types, including non-small-cell lung cancer at metastatic stage to evade the cytotoxic T-cell population, by imitating their immune responses [7, 36]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.