DSC2 and hepatocellular carcinoma: The results showed that the expression of DSC2 protein in HCC cell lines SMMC-7721 (P < 0.01), Huh7 (P < 0.001), HCC-LM3 (P < 0.001), and MHCC-97H (P < 0.001) were all significantly down-regulated compared with L02 cells (Figure 1).