In general, the absolute protein expressions of several transporters, i.e., Abcg2, Abcc4, Abca1, ASCT1, GLUT1, ENT1, and OAT3, were more than twofold higher in 5xFAD mice compared to TgF344-AD rat model (Fig. 2a). The gene discussed is SLC22A8; the disease is Alzheimer disease.