The results of immunofluorescence staining and Western blotting showed that MCAO/R significantly regulates the occurrence of ERS, as demonstrated by an increase in the expression of GRP78, p-PERK/PERK, p-IRE1/IRE1, ATF6, Caspase12 and CHOP in the vehicle group compared to the sham group (Figures 6-8). Here, HSPA5 is linked to amelogenesis imperfecta type 1G.