Tumor size (p=0.006), lymphatic invasion (p=0.018), vascular invasion (p=0.025), perineural invasion (p=0.019), MUC1 IRS scores (p=0.018), and MUC1 IRS scores >8.5 (p=0.018) were significant predictors for lymph node metastasis. The gene discussed is MUC1; the disease is neoplasm.