We found that tumor size (p=0.006), lymphatic invasion (p=0.018), vascular invasion (p=0.025), perineural invasion (p=0.019), mean MUC1 IRS score (p=0.018), and MUC1 IRS scores >8.5 (p=0.018) were significant predictors for lymph node metastasis (Table 5). This evidence concerns the gene MUC1 and metastatic malignant neoplasm in the lymph nodes.