Western blot assays revealed that forced LINC01138 expression in colon cancer cells SW480 increased the expression of diacylglycerol kinase eta (DGKH) and Phosphodiesterase 4D (PDE4D), whereas resulted in decrease the expression of pyrroline‐5‐carboxylate reductase 1 (PYCR1) and transketolase (TKT). This evidence concerns the gene PDE4D and malignant colon neoplasm.