According to the molecular structure of the PEDV genome drawn, the ORF1a and ORF1b regions start from the 5′-end cap, and the polyproteins ppla and pp1ab translated from its replicase gene are post-translationally cleaved by internal proteases, resulting in 16 mature end-product nonstructural proteins nsp1–16 [4,70], mainly playing a role in virus infection; this can inhibit the immune responses of the host and create a favorable environment for virus infection and proliferation [71]. This evidence concerns the gene SH2D3A and viral infectious disease.