Moreover, the depletion of CD4+ and CD8+ T cells or deficiency of T cells in Rag1−/− mice resulted in higher viral loads after infection of ZIKV, but adoptive transfer of CD8+ T cells from ZIKV-infected mice reversed this effect [18,27,28], thus, indicating a pivotal role of T cells in the anti-ZIKV immunity. The gene discussed is CD8A; the disease is infection.