In a lung cancer cell, H4K5 acetylation and H3K4 trimethylation induced by sodium 4-phenylbutyrate (4PBA) were replaced by TXNIP-dependent sodium butyrate (NaBu) as they promote the WDR5 expression leading to the initiation of caspase 3/7 and induction of apoptosis [68]. The gene discussed is WDR5; the disease is lung cancer.