In the present case, out of the five genes we envisaged, four genes, ACE2, CD147, FURIN, and TMPRSS2, which serve as the receptors and co-receptors for SARS-CoV-2 and are overexpressed during COVID-19 infection and in the periodontal tissues of periodontitis patients too, presenting with inflammation, periodontal pathogens, and damage-induced pyroptosis [14], are required to be reduced to an average level. The gene discussed is TMPRSS2; the disease is periodontitis.