Another adjuvant, the lung surfactant (PS)-mimetic liposome (containing the interferon gene inducer STING agonist 2′,3′-cyclic guanosine-phosphate adenosine (cGAMP)), when formulated with the influenza vaccine, strongly enhanced influenza vaccine-induced humoral and CD8+ T-cell immune responses in mice and exhibited good activity against distant H1N1 and heterosubtypic H3N2, H5N1, and H7N9 viruses [69]. This evidence concerns the gene CD8A and influenza.