CD8+ T cells express low overall CCR2 and are not sensitive enough to N-CCL2 to still infiltrate tumors; myeloid-derived suppressor cells, however, expressing high levels of CCR2, can still recognize the nitrated form of CCL2 and are thus not hindered in tumor entry, further contributing to the suppressive environment hostile to T cell function [53]. This evidence concerns the gene CCL2 and neoplasm.