To date, ectopic chemokine receptor expression for improved CAR T cell trafficking into tumors has been shown to be a viable strategy for the chemokine receptors CCR2, CCR4, CCR8, CXCR1, CXCR2, CXCR5, CXCR6 and CX3CR1 in different tumor entities [16,93,94,95,96,97,98,99,100,101,102,103,104,105]. Here, CXCR5 is linked to neoplasm.