HLA alleles A*24, C*02, DRB1*12, and DQA1*02 were significantly associated with asymptomatic COVID-19 and A*29, A*33, B*13, DRB1*10, DRB*15, and DRB1*30 were significantly associated with symptomatic COVID-19. The gene discussed is HLA-DRB1; the disease is COVID-19.