HLA-DRB1 and infection: However, we observed only HLA-DRB1*15 association with symptomatic infection in 39.30% of RTRs, an in silico study has shown that HLA-DRB1*15 alleles can bind with different variants of SARS-CoV-2 peptides with multiple binding sites and present it to T and B cells with the highest capacity and generate a potent immune response, which is associated with a humoral immune response as seroconversion.