IFNG and infectious meningitis: In addition, Li et al. [35] observed a positive correlation between IL-6 and IFN-γ concentrations in the cerebrospinal fluid of patients with EV71-associated meningitis, and Mcloughlin et al. [36] also reported that IFN-γ can regulate IL-6 signaling through sIL-6R, suggesting that EV71-induced IFN-γ secretion may enhance IL-6 production.