The contributions of this paper are three-fold: (1) signifying genomic (MND1 (meiotic nuclear divisions 1), CDC6 (cell division cycle 6), ZNF282 (zinc finger protein 282) benefits and adverse effects of the COVID-19 vaccine BNT162b2 in two heterogeneous populations; (2) pointing to a new direction of COVID-19 studies, i.e., gene–gene interactions; (3) pointing to a potential target of next-generation vaccines, antiviral drugs, treatments, and management. The gene discussed is CDC6; the disease is COVID-19.