IL6 and digestive system disorder: Despite the existence of the epithelial layer, which acts as a protective barrier in the gastrointestinal tract, ingested materials and pathogens can cause inflammation by activating the epithelium, neutrophils, and macrophages to produce inflammatory mediators such as cytokines, including interleukin-6 (IL-6), with the consequent generation of reactive oxygen species (ROS), leading to various gastrointestinal disorders, such as gastric ulcers [5,6].