CD4 and neoplasm: Splenic CD8+ T cells harvested from either no TX group or pIL-12 GET treatment group, these cells were capable of producing the key effector cytokines IFN-γ and granzyme B (Figure 5H–J), the splenic CD8+ T cells from tumor-bearing mice induced higher IFN-γ production from day 8 compared to CD4+ T cells (Figure 5H).