MAPT and early-onset autosomal dominant Alzheimer disease: For example, Alzheimer’s disease (AD) is distinguished by the presence of intracellular neurofibrillary protein aggregates known as neurofibrillary tangles (NFTs), which are composed of tau proteins, as well as extracellular β-amyloid (Aβ) accumulation that results in hyperphosphorylated, prion-like misfolded oligomers [44].