Whereas NETs play a driving role in tumor growth, metastasis, and invasion and in cancer cell immune escape [189,194,206,222,223] and can awaken dormant cancer cells [200] and promote CAT [224,225], leading to the malignant transformation of tumors and poor prognosis, the degradation of NETs through DNase Ι or the inhibition of NETosis through PAD4 inhibitor treatment are important to the prevention and treatment of disease. Here, PADI4 is linked to cancer.