For example, a recent study revealed that persistent inflammation induced by environmental toxins, such as tobacco smoke toxins, induces NET formation, which activates the integrin α3β1 pathway and FAK/ERK/MLCK/YAP signaling by releasing NE and MMP9 and triggering laminin cleavage and remodeling; this pathway awakens dormant cancer cells and promotes their proliferation [200]. This evidence concerns the gene PTK2 and cancer.