In addition, the upregulation of PAD4 expression inhibited the radiosensitivity of NPC cells and promoted their proliferation, migration and invasion, while PAD4 inhibitors, GSK484 and YW3-56 effectively reversed these effects and significantly inhibited tumor growth in mice [240,241], suggesting that the combination of PAD4 inhibitors and radiotherapy is a feasible treatment of NPC. This evidence concerns the gene PADI4 and nasopharyngeal carcinoma.