Similar observations are reported in CRC cells by Yichum et al. The involvement of interleukin (IL)-6/signal transducer and activator of transcription-2 (STAT-3) pathway in suppressing the Warburg effect was clearly observed from the inhibition of pro-inflammatory cytokines (IL-6) and microRNA (miR-155). This evidence concerns the gene IL6 and colorectal carcinoma.