MYC and cancer: Recently, the G4 binding properties of trans-polydatin (5, Figure 1), the 3-β-D-glucoside form of the polyphenol trans-resveratrol (6) [95], a plant-derived compound known for its numerous therapeutic effects [96,97], were explored using three cancer-related G-rich DNA targets, including a G-rich region found in the promoter of the c-myc oncogene.