For instance, it was observed that adding to the standard anti-diabetic therapy (mainly metformin or glibenclamide) hydroalcoholic extract of stinging nettle (45% ethanol, 55% water and 2.7 g of dry plant in 1 L extract) 100 mg/kg in 3 portions a day (after each main meals) for 8 weeks, was not superior to placebo in affecting insulin concentration and insulin sensitivity in patients of both genders (29.2% man and 49.3% women) with T2DM (mean duration of diabetes at baseline more than 8 years, HbAc1 ≤ 10%) [251]. Here, INS is linked to diabetes mellitus.