IGFBP4 and diabetes mellitus: An apparent effect on fasting glucose was observed already after 12 weeks of 320 mg anthocyanins extracted from natural bilberry and blackcurrant administrated to subjects with newly diagnosed diabetes in the NCT02689765 study [277,279,280,281], in which a parallel increase in serum insulin-like growth factor binding protein-4 (IGFBP-4) fragment was reported.