A Pt(II) complex (Pt1) coordinated by a bidentate cyclometalated ligand, a monodentate N-heterocyclic carbene ligand and a chloride anion, able to repress VEGF expression in cancer cells, was studied in its interaction with the unimolecular parallel G-quadruplex VEGF of sequence d(CGGGGCGGGCCTTGGGCGGGGT). This evidence concerns the gene VEGFA and cancer.