PLAU and cancer: For instance, cancer-associated proteases (CAPs), including urokinase plasminogen activator (uPA) and membrane-type matrix metalloproteinase (MMP), catalyze the hydrolysis reaction of caged liposomes, which disintegrate via osmotic swelling of the liposome core once the consensus sequence peptide of μPA (Ser-Gly-Arg-Ser-Ala) is cleaved in the polymer cage [211].