EIF4E and acute myeloid leukemia: In addition, the morphological changes of AML cells were illustrated when stained with Wright-Giemsa, and cells with knockdown of eIF4E showed an indentation and bending of the nuclei and a decrease in nuclear/cytoplasmic ratio, suggesting a terminally differentiated tendency in eIF4E-depleted cells (Molm13, Figure 2D; NB4, Figure S3G).