Our results showed that ATRA and ATPR decreased the protein level of eIF4E in the four AML cell lines (NB4, Molm13, MV4-11, and THP-1) (Figure 1E), and subsequent results found in the immunofluorescence staining assay also confirmed that ATRA and ATPR inhibited endogenous eIF4E levels (Figure 1F). This evidence concerns the gene EIF4E and acute myeloid leukemia.