Besides, we noted that eIF4E impeded the process of AML cell maturation, as sustained eIF4E inhibited the induction of CD11b expression by ATRA or ATPR (Figure 2G), suggesting that the inhibition of eIF4E was critical to maintaining the effect of ATRA or ATPR on AML cell differentiation. The gene discussed is ITGAM; the disease is acute myeloid leukemia.