TNF and arthritic joint disease: Alaaeldin et al. [15] have demonstrated the efficacy of spanlastic nanovesiclular system for ameliorating the anti-inflammatory effect of the selective COX-2 inhibitor, celecoxib, in an adjuvant-induced arthritis (AIA) rat model, via suppression of the proinflammatory markers, tumor necrosis factor alpha (TNF-α), and nuclear factor kappa-B (NFкB).