BCL2 and melanoma: As reported by Hatiboglu et al., TQ induced apoptosis by the blocking of the Janus kinase 2 (JAK2)/signal transducer and the activator of the transcription 3 (STAT3) pathway and, as a consequence, decreased the expression of anti-apoptotic proteins (Bcl-2 and survivin), and increased the expression of pro-apoptotic proteins, such as BAX and caspase 3, in B16F10 murine melanoma cells, within 24 h [13].