Importantly, our results of pharmacokinetics and urinary excretion behaviors of furosemide and PAH were identical to those obtained by Eraly et al. [33], indicating that the phenotype of KO rats can be wholly attributed to the knockout of Slc22a6 and Slc22a8, and the LOC102550957 gene between appears not have a function. Here, SLC22A8 is linked to pulmonary arterial hypertension.