NCOA4 and Alzheimer disease: Ginkgolide B, a terpene lactone derivative of Ginkgo biloba, has been revealed by Shao et al. to ameliorate AD-related cognitive impairment in senescence-accelerated P8 (SAMP8) mice, through reducing iron content in the brain, decreasing transferrin receptor 1 (TFR1) and nuclear receptor coactivator 4 (NCOA4) expressions, increasing ferritin heavy chain (FTH1) expression, and activating the Nrf2/GPX4 signaling pathway [20].