Salidroside, a precious phenylethanoid glycoside derived from Rhodiola, has been found by Yang et al. to effectively decrease the levels of intracellular Fe2+ to attenuate lipid peroxidation and mitochondrial damage in glutamate-induced HT22 cells, while increasing expressions of GPX4 and solute carrier family 7 membrane 11 (SLC7A11) and activating the Nrf2/HO1 signaling pathway in Aβ1-42-induced AD mice [21]. The gene discussed is GPX4; the disease is Alzheimer disease.