TLR9 and neoplasm: Co-encapsulation of antigenic ovalbumin with TLR9 and STING ligands in liposomes revealed that pH-sensitive liposomes co-encapsulating CpG ODN and cGAMP induced synergistic innate immune responses by increasing type I and type II interferon levels, and that ovalbumin caused specific Th1-biased immune enhancement and induced reversal of the immunosuppressive TME while enhancing effective anti-tumor immune responses [186].