■ no cytotoxic effects on human neuroblastoma SH-SY5Y cells ↑ SH-SY5Y cells’ viability against Aβ1–42 due to their markedly free radical scavenging properties and abrogated reactive oxygen species generation via the p38-MAPK/JNK pathways↑ induced Nrf2 and HO-1 expression ↓ Alzheimer’s markers APP, BACE-1, neuroinflammatory markers ρ-NF-kB, TNF-α and iNOS, and neuroapoptotic markers Bcl2, Bax, and caspase-3 protein expressions. The gene discussed is MAPK8; the disease is neuroblastoma.