■ modulated mitochondria functionality in neuroblastoma SH-SY5Y cells, by ↑ mitochondrial respiratory chain complexes I and II, and preserved the mitochondrial membrane potential in the presence of rotenone thanks to their ability to reach mitochondria ■ protected neuroblastoma SH-SY5Y cells against rotenone and glutamate-induced toxicity. This evidence concerns the gene NDUFV1 and neuroblastoma.