MAPT and Alzheimer disease: ■ ameliorated memory impairments in the Aβ1–42 mice model of Alzheimer’s disease in a more efficient way than free-anthocyanins■ protected pre- and postsynaptic proteins from Aβ1–42-induced synaptic dysfunction in Aβ1–42-injected mice■ regulated the p-PI3K/p-Akt/p-GSK3β pathway, preventing the hyperphosphorylation of tau protein at serines 413 and 404 in the Aβ1–42- mice model of Alzheimer’s disease■ inhibited apoptosis in the Aβ1–42- mice model of Alzheimer’s disease