LEP and Insulin resistance: So far, their encapsulation with anthocyanins has already shown remarkable healing activity in oral cavity wounds of rats [163]; the ability to improve insulin resistance and glucose intolerance, by increasing the anti-hyperglycemic/anti-diabetic ratios with no apparent toxicity; and lowering animal weight and plasma levels of insulin, glucose, leptin, and total cholesterol in obese mice at 300 mg/kg of body weight [4].