■ coated anthocyanins can successfully cross the blood–brain barrier, reach, and be accumulated in Alzheimer’s disease mice model■ prevent tau hyperphosphorylation and ↓ Amyloid beta, BACE-1, and RAGE expressions, and reduce neuro-inflammatory and oxidative stress markers via GSK-3β/CDK5 pathway. Here, MAPT is linked to Alzheimer disease.