CDK5 and Alzheimer disease: For example, nano-niosomes can give anthocyanins a remarkable ability to cross the blood–brain barrier, reach it, and accumulate in mice with Alzheimer’s disease treated for 14 days, thus preventing tau hyperphosphorylation and reducing the expression of amyloid beta, beta-site amyloid precursor protein cleaving enzyme 1, and advanced glycation end products receptor, and neuroinflammatory and oxidative stress markers via the GSK-3β/CDK5 pathway [204].