After RNA interference with 9 homologues genes of M. incognita (Mi-unc-13, Mi-elo-1, Mi-odr-10, Mi-egl-8, Mi-plc-1, Mi-odr-7, Mi-gpa-6, Mi-osm-9 and Mi-gpa-11), the perception and infection abilities of M. incognita for tomato root were significantly weakened. The gene discussed is MITF; the disease is infection.