To that end, we first developed a clinically relevant mouse model of allergic diarrhea, for which IgEwasthe main mediator and in which challenge wasperformed by oral administration of allergens, similar to what occurs in humans.The increased levels of specific IgE/IgG, histamine, mast cells, and Th1-, Th2-, and Th17-related cytokine cells, symptoms of systemic anaphylaxis, reduced body temperature, and histopathological changes validated the sensitivity to MLP in BALB/c mice. The gene discussed is IGHE; the disease is anaphylaxis.