In the present narrative review on IPA and T2D and fatty liver disease, we will extend our analyses on the available IPA data that we have published earlier to explore the putative interactions between IPA and well-known genetic variants (TCF7L2, FTO, and PPARG) that were associated with the risk of T2D in DPS study participants [20]. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.