The supplementation demonstrated an improvement in obesity indicators (weight, body mass index, waist circumference), lipid profile, glycemic markers (insulin, fasting blood glucose HOMA-IR), leptin, adiponectin and neuropeptide Y. The improvement in these parameters in the chitosan supplementation group has been confirmed in the comparison with the placebo cluster [173]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.