Besides amelioration of general fitness and supporting weight loss, exercise has been associated with multiple positive effects on the health of children and adolescents with overweight or obesity, such as improved insulin sensitivity, cardiovascular and endothelial function, lower low-density lipoprotein levels and higher high-density lipoprotein levels, and reduced risk of morbidity and mortality [11,85,86]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.