In our study, after B. breve CCFM1067 intervention, PD mice exhibited a significant improvement in motor dysfunction, a significant reduction in dopaminergic neuron loss, increased neurotransmitter levels in the striatum, and restored BDNF and GDNF expression, suggesting B. breve CCFM1067 has a neuroprotective effect against MPTP-induced PD. Here, GDNF is linked to Parkinson disease.