In univariable analysis, old age, male sex, DM, hypertension, elevated values of SBP, DBP, BMI, fasting glucose, total cholesterol, triglycerides, hemoglobin and uric acid, decreased eGFR, high values of GGT, albumin ALT and AST, and low total bilirubin were correlated with new-onset hyperuricemia. The gene discussed is GPT; the disease is Hypertension.