The logistic regression model adjusted for smoking and family history of cancer revealed that in the genotypic model carriers of the VDR BsmI rs1544410-AA genotype were associated with a lower risk of developing NSCLC compared to the GG genotype (p = 0.0377; OR = 0.51; CI95% = 0.27–0.95; AA vs. GG). This evidence concerns the gene VDR and cancer.