These excess calories can cause chronic low-grade inflammation, as adipocyte hypertrophy in obesity results in increased infiltration of macrophages into adipose tissue, which secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) [4,5]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.