Hypertension, diabetes, the deficiency of vitamin D and erythropoietin, proteinuria, high concentrations of fibroblast growth factor 23 (FGF-23), elevated uremic toxins and also the accumulation of advanced glycation end-products (AGEs) are the causes of endothelial dysfunction in CKD [15,16]. The gene discussed is EPO; the disease is Hypertension.