CKD individuals had significantly higher serum fibrinogen concentrations (p < 0.001), higher HgbA1c levels (p = 0.018) and higher OPG concentration (p < 0.001), but they had lower hemoglobin (Hgb) and PAI-1 levels (p < 0.001, p = 0.015). The gene discussed is SERPINE1; the disease is chronic kidney disease.