The levels of important proteins in the pyroptosis signaling pathway, including NLRP3 and caspase1, were analyzed in Figure 5E. The expression of NLRP3 and caspase1 were remarkably higher (p = 0.0005, p = 0.0267), PAOS or glibenclamide downregulated the levels of NLRP3 and caspase1 (p = 0.0243, p = 0.001, p = 0.0475; p = 0.0336, p =0.001, p = 0.0013) in DM, suggesting that PAOS or glibenclamide downregulated the pyroptosis signaling pathway. Here, NLRP3 is linked to diabetes mellitus.