MAPK8 and diabetes mellitus: The expressions of key components in the TLR4/MAPK/NF-κB signaling pathway are shown in Figure 5A. Compared with the control group, the levels of some important proteins (including, P-p38, P-ERK1/2, P-JNK1/2/3 and P-p65) in TLR4/MAPK/NF-κB pathway were higher (p = 0.0722, p = 0.0329, p = 0.0077, p = 0.0012) in DM.