However, three out of five meta-analysis [38,43,44,45,46] reported an increased risk of CRC development for MTRR G allele and/or GG genotype in Caucasians [38,44] and in Asians [46], suggesting a race-specific effect of MTRR rs1801394 on CRC. The gene discussed is MTRR; the disease is colorectal carcinoma.