Others, including our previous analysis based on the Newfoundland Familial Colorectal Cancer Study (hazard ratio (HR) = 1.72) [27] and a recent meta-analysis (HR = 1.85) [26], have reported a shorter overall survival in patients with MTHFR A1298C CC genotype compared to those with CA/AA genotypes. The gene discussed is MTHFR; the disease is colorectal cancer.