MTHFR and colorectal carcinoma: Of the 16 SNPs in the MTHFR gene, 8 SNPs specifically, rs3737966 (G vs. A allele), rs4846049 (T vs. G allele), rs1476413 (A vs. G allele), rs1801131 (C vs. A allele), rs12121543 (A vs. C allele), rs4846052 (T vs. C allele), rs2066471 (A vs. G allele), and rs7533315 (T vs. C allele), were correlated with decreased CRC-specific survival in all cases (Supplementary Table S2 and Figure 1A).