In a study by Nan S. et al. It was demonstrated that EGCG may diminish the hyperphosphorylation of the Tau protein, and downregulate Beta-Secretase 1 and β-amyloid 1–42 expression to improve the antioxidant system and learning and memory function of rats with Alzheimer disease [110]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.